CoLabs supports UCSF and external investigators with studying the diversity and dynamics of the immune microenvironment across a variety of diseases.
CoLabs has experience incorporating multiple techniques and tissue types and can assist you with your experiment from design to analysis.
To get started, please contact Disease to Biology CoLab to discuss your project. From there, you will work with additional CoLabs Teams depending on your project. You can take advantage of the complementary platforms, expertise, and collaborative culture at CoLabs. Our labs are located near each other to streamline communication and workflows.
Immune monitoring is a highly collaborative project between you and multiple CoLabs Teams. We will train you in techniques such as multi-parametric flow and mass cytometry, single cell -omics, and data integration. Please contact Disease to Biology CoLab to learn more.
Our CoProject collaborators will have the opportunity to learn and work side-by-side with CoLabs experts. Visit CoProjects to see if your research is suitable or contact our Chief Strategist Andrea to learn more about our collaborative research model.
Immunity and cancer
The CoLabs Initiative was created to tackle the growing need for complex data generation and analysis that arises from multidisciplinary research. This combination of resource sharing, technical know-how, and computational expertise at CoLabs allowed the seamless advancement of using multiple approaches in the form of the ImmunoProfiler CoProject. We examined 12 cancer types from hundreds of tumors using several methods and discovered common immune system archetypes. You can read more in our Cell publication.
Expanding on the success of ImmunoProfiler, we are currently working on AutoImmunoProfiler to characterize autoimmune diseases using transcriptomic, epigenomic, and proteomic analyses on tissue and blood samples. Partnering with Eli Lilly, we aim to identify targets for drug development. AutoImmunoprofiler is now seeking to identify additional partners for studies of these and other immune-mediated human diseases.
Immunity and COVID
The ImmunoProfiler model paved the way for UCSF’s rapid response to COVID-19 at the onset of the pandemic. CoLabs, in collaboration with UCSF colleagues and researchers around the world, was able to quickly implement studies addressing the pathogenic process and host immune response. These results helped identify biomarkers and develop therapeutics, and we continue to investigate coronavirus as part of the COMET Consortium. CoLabs has since expanded into other disease areas and increased our network of scientists.
1. Where are you located?
CoLabs is located in Parnassus Heights at UCSF. Our labs are concentrated on the 8th floor of the Medical Sciences Building, with a few instruments in other sites.